Glioblastoma
The most aggressive primary brain tumor in adults, growing rapidly and infiltrating surrounding brain tissue, causing headache
Symptoms
- Persistent headache
- Seizures
- Nausea and vomiting
- Blurred vision
- Weakness in arms or legs
- Difficulty speaking
- Memory problems
- Personality changes
- Confusion
- Loss of balance
- Difficulty walking
- Drowsiness
The most aggressive primary brain tumor in adults, growing rapidly and infiltrating surrounding brain tissue, causing headache, seizures, and progressive neurological deficits. The cause is largely unknown, arising from glial cells. Standard treatment is maximal safe surgical resection using intraoperative MRI or fluorescence guidance (5-ALA), followed by radiotherapy with concurrent and adjuvant temozolomide chemotherapy. Tumor-treating fields (wearable electric field devices) are a newer FDA-approved addition that modestly extends survival. Despite treatment, prognosis remains guarded, driving ongoing research into immunotherapy and targeted molecular therapies.
